Thermal effect of endoscopic thermal vapour ablation on the lung surface in human ex vivo tissue
نویسندگان
چکیده
PURPOSE An investigation of the thermal effect and the potential for injury at the lung surface following thermal vapour ablation (InterVapor), an energy-based method of achieving endoscopic lung volume reduction. METHODS Heated water vapour was delivered to fifteen ex vivo human lungs using standard clinical procedure, and the thermal effect at the visceral pleura was monitored with an infrared camera. The time-temperature response was analysed mathematically to determine a cumulative injury quotient, which was compared to published thresholds. RESULTS The cumulative injury quotients for all 71 treatments of ex vivo tissue were found to be below the threshold for first degree burn and no other markers of tissue injury at the lung surface were observed. CONCLUSION The safety profile for thermal vapour ablation is further supported by the demonstration that the thermal effect in a worst-case model is not expected to cause injury at the lung surface.
منابع مشابه
An Investigation of Brightness Changes in Ultrasound Images due to Temperature Variations in Liver Tissue during Radiofrequency Ablation
Introduction: one of the minimally invasive methods of treatmenting liver malignancies is Radiofrequency Ablation (RFA) which can be applied to primary or secondary tumors. Nevertheless, the disease recurrence is probable after RFA application partially due to the inadequate capability of temperature monitoring of the target tissue and visualizing the thermal damage. The goal of this work was t...
متن کاملA Multi Objective Genetic Algorithm (MOGA) for Optimizing Thermal and Electrical Distribution in Tumor Ablation by Irreversible Electroporation
Background: Irreversible electroporation (IRE) is a novel tumor ablation technique. IRE is associated with high electrical fields and is often reported in conjunction with thermal damage caused by Joule heating. For good response to surgery it is crucial to produce minimum thermal damage in both tumoral and healthy tissues named Non-Thermal Irreversible Electroporation(NTIRE). Non-thermal irrev...
متن کاملSynthesis of carbon nano structures on Fe/Cu/AI and Al/Steel by thermal chemical vapour deposition method
Using C2H2, 112 and As gases at 550'C, carbon nanotubes were fabricated on the surfaces of twosubstrates coated by nano thin layers of metal catalysts by DC magnetron sputtering. AYStamless steel andFe/CteAl, by thermal chemical vapor deposition (TCVD) The surface properties of the substrates wereparticularly investigated, and the effect of treatment of the substrates on the CNT's growth is cri...
متن کاملEx Vivo Liver Tissue Radiofrequency Thermal Ablation: Ir Measurements and Simulations
Radiofrequency thermal ablation (RFTA) is a medical procedure currently widely adopted for liver tumors treatment. Its outcome is strongly influenced by temperature distribution near the RF applicator therefore continuous measurements are required both to validate RFTA numerical models and to better control the outcome of the procedure. The space-time evolution of the thermal field during RFTA ...
متن کاملEx vivo histological characterization of a novel ablative fractional resurfacing device.
BACKGROUND AND OBJECTIVES We introduce a novel CO(2) laser device that utilizes ablative fractional resurfacing for deep dermal tissue removal and characterize the resultant thermal effects in skin. STUDY DESIGN/MATERIALS AND METHODS A prototype 30 W, 10.6 microm CO(2) laser was focused to a 1/e(2) spot size of 120 microm and pulse duration up to 0.7 milliseconds to achieve a microarray patte...
متن کامل